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The rapid evolution of next-generation advanced manufacturing technologies, exemplified by additive manufacturing, has drastically expanded the accessible compositional and processing windows for metallic materials. These advances actively drive the formation of far-from-equilibrium structures and open unprecedented opportunities to design multiscale nanostructured metals with exceptional structural and functional properties. In this mini-review, we examine how multiscale nanostructural design is driven by both top-down and bottom-up advanced manufacturing routes, elucidating the underlying thermodynamic, kinetic, and geometric driving forces.